Title : Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.

Pub. Date : 1996 Aug 1

PMID : 8764657






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A peptide inhibitor of ICE-like protease activity, Ac-YVAD-chloromethylketone (Ac-YVAD-CMK), prevents K+ deprivation-induced apoptosis. ac-yvad C-X-C motif chemokine ligand 9 Homo sapiens
2 Using fluorescent assays, we show that ROS production after K+ deprivation is blocked by actinomycin D, cycloheximide, and Ac-YVAD-CMK, suggesting that ROS act downstream of gene transcription, mRNA translation, and ICE activation. ac-yvad C-X-C motif chemokine ligand 9 Homo sapiens