Pub. Date : 1996 Aug
PMID : 8764619
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | [11C] PHY retention was higher in regions rich in AChE, such as the striatum (half-life, 35 min), than in regions poor in AChE, such as the cerebral cortex (half-life, 20 min). | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | At later times (25-35 min postinjection), the cerebral distribution of [11C]PHY was typical of AChE activity: putamen-caudate > cerebellum > brainstem > thalamus > cerebral cortex, with a striatal to cortex ratio of 2. | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | These results suggest that PET studies with [11C]PHY can provide in vivo brain mapping of human AChE and are promising for the study of changes in AChE levels associated with neurodegenerative diseases. | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | These results suggest that PET studies with [11C]PHY can provide in vivo brain mapping of human AChE and are promising for the study of changes in AChE levels associated with neurodegenerative diseases. | Carbon-11 | acetylcholinesterase (Cartwright blood group) | Homo sapiens |