Title : Indapamide accentuates cardiac chronotropic responses to epidermal growth factor in chick cardiomyocytes.

Pub. Date : 1996 Aug

PMID : 8760860






5 Functional Relationships(s)
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1 Indapamide accentuates cardiac chronotropic responses to epidermal growth factor in chick cardiomyocytes. Indapamide epidermal growth factor Gallus gallus
2 This study sought to examine the potential interaction between indapamide and epidermal growth factor (EGF). Indapamide epidermal growth factor Gallus gallus
3 This study sought to examine the potential interaction between indapamide and epidermal growth factor (EGF). Indapamide epidermal growth factor Gallus gallus
4 Indapamide enhanced the positive chronotropic response to EGF observed in chick embryonic ventricular myocyte aggregates while indapamide itself did not alter cardiac contractile frequency. Indapamide epidermal growth factor Gallus gallus
5 Taken in conjunction with data that calcium channel blockade, inhibition of sodium entry or Na(+)-Ca2+ exchange in the cardiomyocyte opposes the positive chronotropic action of EGF on the cardiomyocyte, this study has identified an agent, indapamide, that accentuates the cardiomyocyte response to EGF. Indapamide epidermal growth factor Gallus gallus