Pub. Date : 1996 Jul
PMID : 8758950
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of MK-801, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, on the kainic acid-induced expression of the inducible heat shock protein 70 kDa (HSP70) and on neuronal death in the rat hippocampus was investigated. | Kainic Acid | heat shock protein family A (Hsp70) member 1B | Rattus norvegicus |
| 2 | The effect of MK-801, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, on the kainic acid-induced expression of the inducible heat shock protein 70 kDa (HSP70) and on neuronal death in the rat hippocampus was investigated. | Kainic Acid | heat shock protein family A (Hsp70) member 1B | Rattus norvegicus |
| 3 | HSP70 is expressed in approximately 80% of the pyramidal neurons in the CA1 field 1 day after kainic acid injection. | Kainic Acid | heat shock protein family A (Hsp70) member 1B | Rattus norvegicus |
| 4 | The majority of these HSP70-immunopositive neurons exhibited swelling and a hollow appearance in the perikaryon, indicating that they had been injured following kainic acid-elicited limbic seizures. | Kainic Acid | heat shock protein family A (Hsp70) member 1B | Rattus norvegicus |
| 5 | When a single dose of MK-801 was given 4 h after kainic acid treatment, HSP70 expression was partially blocked; 18% of neurons expressed HSP70 on day 1 and 37% on day 4 in CA1 pyramidal neurons in comparison to the kainic acid controls. | Kainic Acid | heat shock protein family A (Hsp70) member 1B | Rattus norvegicus |