Pub. Date : 1996 Aug 14
PMID : 8753812
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF). | Tetradecanoylphorbol Acetate | colony stimulating factor 3 | Homo sapiens |
| 2 | G-CSF protein was neither produced during PMA-induced differentiation nor in response to retinoic acid (RA) alone. | Tetradecanoylphorbol Acetate | colony stimulating factor 3 | Homo sapiens |
| 3 | The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. | Tetradecanoylphorbol Acetate | colony stimulating factor 3 | Homo sapiens |
| 4 | The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. | Tetradecanoylphorbol Acetate | colony stimulating factor 3 | Homo sapiens |
| 5 | It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway. | Tetradecanoylphorbol Acetate | colony stimulating factor 3 | Homo sapiens |