Title : Electrostatic control of GTP and GDP binding in the oncoprotein p21ras.

Pub. Date : 1996 Apr 15

PMID : 8740369






3 Functional Relationships(s)
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1 Electrostatic control of GTP and GDP binding in the oncoprotein p21ras. Guanosine Diphosphate HRas proto-oncogene, GTPase Homo sapiens
2 The GTP-bound form of p21ras sends a growth-promoting signal that is terminated once the protein is cycled back into its GDP-bound form. Guanosine Diphosphate HRas proto-oncogene, GTPase Homo sapiens
3 RESULTS: The crystal structures of p21ras are correlated with the binding affinities of GTP and GDP by calculating the relevant electrostatic energies. Guanosine Diphosphate HRas proto-oncogene, GTPase Homo sapiens