Pub. Date : 1996 May
PMID : 8727261
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mechanism of action of disulfiram involves inhibition of hepatic aldehyde dehydrogenase (ALDH). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 2 | The mechanism of action of disulfiram involves inhibition of hepatic aldehyde dehydrogenase (ALDH). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 3 | Although disulfiram inhibits ALDH in vitro, it is believed that the drug is too short-lived in vivo to inhibit the enzyme directly. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 4 | MeDTC sulfoxide and MeDTC sulfone, in 10-min incubations with detergent-solubilized mitochondria, inhibited ALDH activity with an IC50 (mean +/- SD) of 0.93 +/- 0.04 and 0.53 +/- 0.11 microM, respectively, compared with 7.4 +/- 1.0 microM for the parent drug disulfiram. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 5 | In contrast, MeDTC sulfoxide is a better candidate for the ultimate active metabolite of disulfiram, because it is more likely to be sufficiently stable to diffuse from a distant site of formation, such as the endoplasmic reticulum, penetrate the mitochondria, and react with ALDH located in the mitochondrial matrix. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |