Title : Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.

Pub. Date : 1996 Aug 20

PMID : 8718893






1 Functional Relationships(s)
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1 Docking of Sp and Rp cycloheptyl methylphosphonyl thiocholines and thioethylates in AChE as models of the reversible complex and transition state using molecular dynamics affords structural insight into the spatial arrangement of the substituents surrounding phosphorus prior to and during reaction. Phosphorus acetylcholinesterase (Cartwright blood group) Homo sapiens