Title : Heparin-induced overexpression of basic fibroblast growth factor, basic fibroblast growth factor receptor, and cell-associated proteoheparan sulfate in cultured coronary smooth muscle cells.

Pub. Date : 1996 Aug

PMID : 8696947






5 Functional Relationships(s)
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Protein Name
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1 Heparin-induced overexpression of basic fibroblast growth factor, basic fibroblast growth factor receptor, and cell-associated proteoheparan sulfate in cultured coronary smooth muscle cells. Heparin fibroblast growth factor 2 Bos taurus
2 Heparin-induced overexpression of basic fibroblast growth factor, basic fibroblast growth factor receptor, and cell-associated proteoheparan sulfate in cultured coronary smooth muscle cells. Heparin fibroblast growth factor 2 Bos taurus
3 Heparin in nanogram quantities may promote or even be required for binding of bFGF to its cognate receptor. Heparin fibroblast growth factor 2 Bos taurus
4 The heparin-induced increase in cellular protein content includes a 60% to 100% increase in the expression of pericellular bFGF, FGF-R1, and cell membrane-integrated HSPG. Heparin fibroblast growth factor 2 Bos taurus
5 These results indicate that heparin, despite its anti-proliferative potency, stimulates the expression of all components of the bFGF system even in coronary SMCs in which growth is inhibited. Heparin fibroblast growth factor 2 Bos taurus