Pub. Date : 1996 Aug
PMID : 8695348
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 2 | Tamoxifen did not induce any consistent increase in TGF-beta secretion into the conditioned medium, but immunofluorescence analysis for the intracellular form of TGF-beta 1 revealed evidence of increased immunoreactive protein in tamoxifen-treated fibroblasts, which is localised to the nucleus. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 3 | Therefore synthesis of TGF-beta 1 appears to be stimulated by tamoxifen, but increased secretion may be abrogated in vitro. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |