Title : Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils.

Pub. Date : 1996 Jul 26

PMID : 8694859






3 Functional Relationships(s)
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1 However, inhibition of superoxide generation by neutrophils activated with phorbol myristate acetate (PMA), opsonized zymosan (OZ), and arachidonate (AA) only occurred with higher concentrations of propranolol, and coincided with decreased intracellular calcium fluxes, phospholipase A2 (PLA2) activity and synthesis of platelet-activating factor (PAF). Superoxides PCNA clamp associated factor Homo sapiens
2 However, inhibition of superoxide generation by neutrophils activated with phorbol myristate acetate (PMA), opsonized zymosan (OZ), and arachidonate (AA) only occurred with higher concentrations of propranolol, and coincided with decreased intracellular calcium fluxes, phospholipase A2 (PLA2) activity and synthesis of platelet-activating factor (PAF). Superoxides PCNA clamp associated factor Homo sapiens
3 A mechanistic relationship between the anti-oxidative and membrane-stabilizing properties of propranolol was suggested by the observation that pretreatment of neutrophils with LPC or PAF eliminated the inhibitory effects of the drug on superoxide generation by PMA-activated neutrophils. Superoxides PCNA clamp associated factor Homo sapiens