Title : Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.

Pub. Date : 1996 Jun 5

PMID : 8660366






3 Functional Relationships(s)
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1 Both in vivo and in Hep3B cells, expression of the erythropoietin gene is induced by hypoxia as well as by certain transition metals (cobalt and nickel) and by iron chelation. Cobalt erythropoietin Homo sapiens
2 Epo induction by cobalt was also affected by iron concentration. Cobalt erythropoietin Homo sapiens
3 Under hyperbaric oxygen, cobalt induction of erythropoietin mRNA was modestly suppressed while nickel induction was markedly enhanced. Cobalt erythropoietin Homo sapiens