Title : Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

Pub. Date : 1996 Jun 1

PMID : 8653697






2 Functional Relationships(s)
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1 Treatment with sulindac not only inhibited tumor formation but decreased small bowel Cox-2 and prostaglandin E(2) to baseline and restored normal levels of apoptosis. Sulindac cytochrome c oxidase II, mitochondrial Mus musculus
2 These data suggest that overexpression of Cox-2 is associated with tumorigenesis in the gastrointestinal epithelium, and that both are inhibited by sulindac administration. Sulindac cytochrome c oxidase II, mitochondrial Mus musculus