Title : Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

Pub. Date : 1996 May 28

PMID : 8643607






1 Functional Relationships(s)
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1 Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10) M dihydrotestosterone or 10(-9) M testosterone, but not 10(-6) M hydroxyflutamide in human prostate cancer DU145 cells. Testosterone androgen receptor Homo sapiens