Pub. Date : 1996 May 15
PMID : 8639791
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PU.1, a member of the ets transcription factor family, has been previously shown to be necessary for tetradecanoylphorbol-13 acetate (TPA)-induced U937 leukemic cell maturation. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 2 | However, TPA treatment induced phosphorylation of PU.1. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 3 | Gel-shift analysis using a labeled PU.1 oligomer showed that TPA induced a unique PU.1 binding activity. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 4 | Gel-shift analysis using a labeled PU.1 oligomer showed that TPA induced a unique PU.1 binding activity. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 5 | The PU.1 binding activity was generated at TPA-13 concentrations stimulating growth arrest and was blocked by the PKC inhibitor GF109203X, which antagonized TPA-induced growth inhibition. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 6 | The PU.1 binding activity was generated at TPA-13 concentrations stimulating growth arrest and was blocked by the PKC inhibitor GF109203X, which antagonized TPA-induced growth inhibition. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 7 | These data suggest that TPA-induced growth inhibition is associated with phosphorylation of PU.1 and generation of a unique PU.1 binding activity. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |
| 8 | These data suggest that TPA-induced growth inhibition is associated with phosphorylation of PU.1 and generation of a unique PU.1 binding activity. | Tetradecanoylphorbol Acetate | Spi-1 proto-oncogene | Homo sapiens |