Title : Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3.

Pub. Date : 1996 Feb

PMID : 8628015






2 Functional Relationships(s)
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1 In both lines, vitamin D3 produced induction of differentiative markers, inhibition of cell proliferation and a decrease of the NM23.H1, NM23.H2 and c-myc genes, behaving both as a differentiative and an antiproliferative agent. Cholecalciferol MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 The fact that the c-myc transcriptional factor PuF is identical to the NM23.H2 gene and that NM23 protein could be a transcriptional factor suggests that the regulatory action exerted by vitamin D3 on c-myc transcription is mediated by NM23.H2. Cholecalciferol MYC proto-oncogene, bHLH transcription factor Homo sapiens