Title : Regulation of phospholipase C-beta1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation.

Pub. Date : 1996 Apr 5

PMID : 8626481






4 Functional Relationships(s)
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1 They also suggest a mechanism in which the receptor, Gq, and PLC form a three-protein complex in the presence of agonist and GTP (stable over multiple GTPase cycles) that is responsible for PLC signaling. Guanosine Triphosphate heparan sulfate proteoglycan 2 Homo sapiens
2 In this system, the muscarinic agonist carbachol stimulated steady-state PLC activity up to 90-fold in the presence of GTP. Guanosine Triphosphate heparan sulfate proteoglycan 2 Homo sapiens
3 Both GTP and agonist were required for PLC activation, which was observed at physiological levels of Ca2+ (10-100 nM). Guanosine Triphosphate heparan sulfate proteoglycan 2 Homo sapiens
4 They also suggest a mechanism in which the receptor, Gq, and PLC form a three-protein complex in the presence of agonist and GTP (stable over multiple GTPase cycles) that is responsible for PLC signaling. Guanosine Triphosphate heparan sulfate proteoglycan 2 Homo sapiens