Title : Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities.

Pub. Date : 1996 Mar 27

PMID : 8623162






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FK506 blocks T cell activation by preventing the transcription of lymphokine genes through binding to the intracellular protein FKBP12 and formation of complex that inhibits the phosphatase activity of calcineurin. Tacrolimus FKBP prolyl isomerase 1A Rattus norvegicus