Title : Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.

Pub. Date : 1996 Apr 16

PMID : 8622986






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PLZF-RARalpha and PML-RARalpha have essentially the same ligand-binding affinities and can bind in vitro to retinoic acid response elements (RAREs) as homodimers or heterodimers with RXRalpha. Tretinoin zinc finger and BTB domain containing 16 Homo sapiens
2 These different protein-protein interactions and the target gene specificities of PLZF-RARalpha and PML-RARalpha may underlie, at least in part, the apparent resistance of APL with t(11;17) to differentiation effects of all-trans-retinoic acid. Tretinoin zinc finger and BTB domain containing 16 Homo sapiens