Title : Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension.

Pub. Date : 1996 Mar

PMID : 8613205






3 Functional Relationships(s)
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1 Salt sensitivity and resistance were studied in relation to a 287-bp insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme gene detected by a polymerase chain reaction method and the haptoglobin phenotype determined by polyacrylamide gel electrophoresis. Salts angiotensin I converting enzyme Homo sapiens
2 Patients with the angiotensin I-converting enzyme gene genotype II were more apt to be salt sensitive than patients with the ID and DD genotypes, although plasma renin activity was similar in each group. Salts angiotensin I converting enzyme Homo sapiens
3 These data suggest that an I/D polymorphism of the angiotensin I-converting enzyme gene is a genetic factor associated with salt sensitivity of blood pressure independently of plasma renin activity in Japanese patients with essential hypertension. Salts angiotensin I converting enzyme Homo sapiens