Title : Mechanism of action of the immunosuppressant rapamycin.

Pub. Date : 1996

PMID : 8594303






1 Functional Relationships(s)
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1 A second, later effect of rapamycin in IL-2-stimulated T cells is an inhibition of the enzymatic activity of the cyclin-dependent kinase cdk2-cyclin E complex, which functions as a crucial regulator of G1/S transition. Sirolimus interleukin 2 Homo sapiens