Title : Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice.

Pub. Date : 1996 Mar

PMID : 8589728






2 Functional Relationships(s)
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1 The adult lung expresses alpha, beta and gamma ENaC (3,4), and an amiloride-sensitive electrogenic sodium reabsorption has been documented in upper and lower airways (3-7), but it is not established whether this sodium transport is mediated by ENaC in vivo. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus
2 Amiloride-sensitive electrogenic Na+ transport was abolished in airway epithelia from alpha-ENaC(-/-) mice. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus