Title : The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats.

Pub. Date : 1995 Oct 15

PMID : 8568688






4 Functional Relationships(s)
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1 Secretin given intravenously at 5.6 pmol kg-1 h-1 inhibited profoundly the acid secretion stimulated by pentagastrin at 0.3 microgram kg-1 h-1. Pentagastrin secretin Rattus norvegicus
2 When a rabbit antisomatostatin serum was given intravenously, it not only abolished the secretin-induced inhibition on the pentagastrin-stimulated acid secretion, but also augmented both basal and pentagastrin-stimulated acid secretion. Pentagastrin secretin Rattus norvegicus
3 When a rabbit antisomatostatin serum was given intravenously, it not only abolished the secretin-induced inhibition on the pentagastrin-stimulated acid secretion, but also augmented both basal and pentagastrin-stimulated acid secretion. Pentagastrin secretin Rattus norvegicus
4 It is concluded that the inhibitory action of secretin on pentagastrin-stimulated gastric acid secretion is mediated by both somatostatin and prostaglandins in conscious rats. Pentagastrin secretin Rattus norvegicus