Title : Induction of the mitochondrial permeability transition by protease activity in rats: a mechanism of hepatocyte necrosis.

Pub. Date : 1996 Feb

PMID : 8566604






2 Functional Relationships(s)
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1 RESULTS: The protease inhibitor Cbz-Leu-Leu-Tyr-CHN2 inhibited both calpain-like protease activity and induction of the MMPT by Ca2+ and tert-butyl hydroperoxide. tert-Butylhydroperoxide chimerin 2 Rattus norvegicus
2 The protease inhibitor Cbz-Leu-Leu-Tyr-CHN2 also delayed the onset of mitochondrial depolarization and cell necrosis during treatment of rat hepatocytes with tert-butyl hydroperoxide, a model of oxidative stress relevant to human disease. tert-Butylhydroperoxide chimerin 2 Rattus norvegicus