Pub. Date : 1996 Jan
PMID : 8564846
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | Normal human fibroblasts depleted of functional p53 by SV40 T antigen or HPV-16 E6, and primary embryo fibroblasts from p53 null mice showed seven- to ninefold increased cytotoxicity by paclitaxel. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | Reduced levels of p53 correlated with increased G2/M phase arrest, micronucleation, and p53-independent paclitaxel-induced apoptosis. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | Reduced levels of p53 correlated with increased G2/M phase arrest, micronucleation, and p53-independent paclitaxel-induced apoptosis. | Paclitaxel | tumor protein p53 | Homo sapiens |