Pub. Date : 1995 Oct
PMID : 8563721
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine acts directly on pituitary GH3 cells to inhibit prolactin promoter activity. | Nicotine | prolactin | Rattus norvegicus |
| 2 | We have employed the GH3 rat pituitary cell line to investigate whether nicotine can regulate prolactin (PRL) gene expression. | Nicotine | prolactin | Rattus norvegicus |
| 3 | We have employed the GH3 rat pituitary cell line to investigate whether nicotine can regulate prolactin (PRL) gene expression. | Nicotine | prolactin | Rattus norvegicus |
| 4 | Nicotine strongly inhibited (45%) transient expression of a construct containing the first 187 base-pairs of the rat PRL promoter cloned upstream of the chloramphenicol acetyl transferase (CAT) gene. | Nicotine | prolactin | Rattus norvegicus |
| 5 | This implies that nicotine acts directly on the GH3 cells to inhibit transcription directed by the PRL promoter. | Nicotine | prolactin | Rattus norvegicus |
| 6 | Nicotine was also observed to yield a concentration-dependent inhibition of the stimulation by thyrotrophin-releasing hormone (TRH) of PRL promoter activity, implying that nicotine can also interfere with hormonal regulation of the PRL gene. | Nicotine | prolactin | Rattus norvegicus |
| 7 | Nicotine was also observed to yield a concentration-dependent inhibition of the stimulation by thyrotrophin-releasing hormone (TRH) of PRL promoter activity, implying that nicotine can also interfere with hormonal regulation of the PRL gene. | Nicotine | prolactin | Rattus norvegicus |
| 8 | Nicotine was also observed to yield a concentration-dependent inhibition of the stimulation by thyrotrophin-releasing hormone (TRH) of PRL promoter activity, implying that nicotine can also interfere with hormonal regulation of the PRL gene. | Nicotine | prolactin | Rattus norvegicus |
| 9 | Nicotine was also observed to yield a concentration-dependent inhibition of the stimulation by thyrotrophin-releasing hormone (TRH) of PRL promoter activity, implying that nicotine can also interfere with hormonal regulation of the PRL gene. | Nicotine | prolactin | Rattus norvegicus |
| 10 | These results suggest that the reduced serum PRL levels that result from smoking may originate in part from decreased transcription of the PRL gene resulting from a direct effect of nicotine on pituitary PRL-secreting cells. | Nicotine | prolactin | Rattus norvegicus |
| 11 | These results suggest that the reduced serum PRL levels that result from smoking may originate in part from decreased transcription of the PRL gene resulting from a direct effect of nicotine on pituitary PRL-secreting cells. | Nicotine | prolactin | Rattus norvegicus |
| 12 | These results suggest that the reduced serum PRL levels that result from smoking may originate in part from decreased transcription of the PRL gene resulting from a direct effect of nicotine on pituitary PRL-secreting cells. | Nicotine | prolactin | Rattus norvegicus |