Title : Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.

Pub. Date : 1995

PMID : 8561474






3 Functional Relationships(s)
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Protein Name
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1 The zaragozic acids are very potent inhibitors of squalene synthase that inhibit cholesterol synthesis and lower plasma cholesterol levels in primates. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens
2 The zaragozic acids are very potent inhibitors of squalene synthase that inhibit cholesterol synthesis and lower plasma cholesterol levels in primates. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens
3 These potent natural product based inhibitors of squalene synthase have potential to be developed either as cholesterol lowering agents and/or as antifungal agents. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens