Title : The preclinical development of bicalutamide: pharmacodynamics and mechanism of action.

Pub. Date : 1996 Jan

PMID : 8560673






1 Functional Relationships(s)
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1 Studies with the LNCaP cell line are particularly interesting, as these cells contain a mutated androgen receptor (codon 868, Thr-->Ala), which behaves idiosyncratically with other antiandrogens (cyproterone acetate and flutamide): both these antiandrogens act as agonists in this cell line and stimulate proliferation. Alanine androgen receptor Homo sapiens