Pub. Date : 1995 Nov
PMID : 8555055
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human neutrophils, plated on fibronectin-coated polystyrene wells, were found to exhibit a prolonged production of superoxide anion (O2-) in response to tumour necrosis factor-alpha (TNF). | Superoxides | tumor necrosis factor | Homo sapiens |
| 2 | Human neutrophils, plated on fibronectin-coated polystyrene wells, were found to exhibit a prolonged production of superoxide anion (O2-) in response to tumour necrosis factor-alpha (TNF). | Superoxides | tumor necrosis factor | Homo sapiens |
| 3 | The TNF-triggered O2- production was significantly reduced by 10 microM prostaglandin E2 (PGE2), which was ineffective at lower doses. | Superoxides | tumor necrosis factor | Homo sapiens |
| 4 | When PGE2 and RO 20-1724 were added together to TNF-triggered neutrophils they caused a marked synergistic inhibition of O2- production. | Superoxides | tumor necrosis factor | Homo sapiens |
| 5 | Moreover, the membrane-permeable analogue of cAMP, dibutyryl cAMP, was found to inhibit the TNF-induced O2- production in a dose-dependent manner. | Superoxides | tumor necrosis factor | Homo sapiens |