Pub. Date : 1993 May
PMID : 8509130
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gangliosides inhibit T-lymphocyte proliferation by preventing the interaction of interleukin-2 with its cell surface receptors. | Gangliosides | interleukin 2 | Homo sapiens |
| 2 | Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). | Gangliosides | interleukin 2 | Homo sapiens |
| 3 | Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). | Gangliosides | interleukin 2 | Homo sapiens |
| 4 | Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). | Gangliosides | interleukin 2 | Homo sapiens |
| 5 | Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). | Gangliosides | interleukin 2 | Homo sapiens |
| 6 | We have investigated the effect of gangliosides on the interaction of IL-2 with its cell surface receptors (IL-2R). | Gangliosides | interleukin 2 | Homo sapiens |
| 7 | Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2. | Gangliosides | interleukin 2 | Homo sapiens |
| 8 | Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2. | Gangliosides | interleukin 2 | Homo sapiens |
| 9 | The immunosuppressive effect was most effective when gangliosides were added during the first 4 hr after IL-2-stimulation, indicating that they acted early in the IL-2 signalling pathway. | Gangliosides | interleukin 2 | Homo sapiens |
| 10 | The immunosuppressive effect was most effective when gangliosides were added during the first 4 hr after IL-2-stimulation, indicating that they acted early in the IL-2 signalling pathway. | Gangliosides | interleukin 2 | Homo sapiens |
| 11 | Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2. | Gangliosides | interleukin 2 | Homo sapiens |
| 12 | Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2. | Gangliosides | interleukin 2 | Homo sapiens |
| 13 | In support of this proposal, gangliosides induced a concomitant dose-dependent decrease in binding of [125I]IL-2 to high-, medium- and low-affinity IL-2R. | Gangliosides | interleukin 2 | Homo sapiens |
| 14 | Ganglioside-treated cells recovered their high-affinity [125I]IL-2 binding after washing. | Gangliosides | interleukin 2 | Homo sapiens |
| 15 | A thin-layer chromatography overlay technique was used to demonstrate that IL-2 binds directly to gangliosides, but not to simple neutral glycolipids or acidic lipids. | Gangliosides | interleukin 2 | Homo sapiens |
| 16 | Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo. | Gangliosides | interleukin 2 | Homo sapiens |
| 17 | Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo. | Gangliosides | interleukin 2 | Homo sapiens |