Pub. Date : 1993 May 14
PMID : 8496909
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism-based inhibitors of prostaglandin omega-hydroxylase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid. | 12-hydroxy-16-heptadecynoic acid | cytochrome P450 4A5 | Oryctolagus cuniculus |
| 2 | 12-Hydroxy-16-heptadecynoic acid has been shown to selectively inactivate cytochrome P450 4A4, a pulmonary cytochrome P450 enzyme that catalyzes the omega-hydroxylation of prostaglandins [Muerhoff, A. S.; Williams, D. E.; Reich, N. O.; CaJacob, C. A.; Ortiz de Montellano, P. R.; Masters, B. S. S. J. Biol. | 12-hydroxy-16-heptadecynoic acid | cytochrome P450 4A5 | Oryctolagus cuniculus |
| 3 | In a continuing effort to develop such agents, the two enantiomers of 12-hydroxy-16-heptadecynoic acid have been stereospecifically synthesized, their absolute stereochemistry confirmed, and the dependence of enzyme inactivation on absolute stereochemistry determined using cytochrome P450 4A4 purified from the lungs of pregnant rabbits. | 12-hydroxy-16-heptadecynoic acid | cytochrome P450 4A5 | Oryctolagus cuniculus |