Title : Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung.

Pub. Date : 1993 May

PMID : 8481234






3 Functional Relationships(s)
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1 In this study, in situ hybridization of Mn-SOD in the lungs of adult rats exposed to air or to 85% O2 for 3 days was performed. Oxygen superoxide dismutase 2 Rattus norvegicus
2 In animals exposed to either air or 85% O2, Mn-SOD transcripts were present in arterioles, the septal tips of alveolar ducts, alveolar type II cells, and mesothelial cells. Oxygen superoxide dismutase 2 Rattus norvegicus
3 The high level of expression of Mn-SOD mRNA in alveolar duct septal tips in both control and O2-exposed animals may be secondary to increased aerobic activity in these regions, which contain collagen and elastin and are important stress-bearing elements in the lung. Oxygen superoxide dismutase 2 Rattus norvegicus