Title : Dahl's salt-resistant normotensive rat has mutations in cytochrome P450(11 beta), but the salt-sensitive hypertensive rat does not.

Pub. Date : 1993 Apr 25

PMID : 8473350






1 Functional Relationships(s)
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1 When the two cDNAs were expressed in COS-7 cells and steroid conversion rates of the transformed cells were determined, a ratio of 18-hydroxylation to 11 beta-hydroxylation of 11-deoxycorticosterone by P450(11 beta)-DS-expressed cells was 0.58, whereas that by P450(11 beta)-DR-expressed cells was 0.23. Desoxycorticosterone cytochrome P450, family 11, subfamily b, polypeptide 1 Rattus norvegicus