Title : Lipoprotein lipase regulation in the cyclophosphamide-treated rabbit: dependence on nutritional status.

Pub. Date : 1993 Jan

PMID : 8445340






9 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lipoprotein lipase regulation in the cyclophosphamide-treated rabbit: dependence on nutritional status. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
2 Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
3 Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
4 The effects of cyclophosphamide on LPL activity and synthesis, depending on the nutritional state, were thus studied in two sites: periepididymal adipose tissue and heart. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
5 Cyclophosphamide administration to the fed rabbit led to decreases of LPL activity and synthesis in the adipose tissue, similar to those observed upon starvation. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
6 However, cyclophosphamide induced opposite effects, depending on the nutritional state: after injection into fed animals, heart LPL activity increased up to 477.2 mIU/g (P < 0.01) with a concomitant increase in the LPL synthesis rate. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
7 However, cyclophosphamide induced opposite effects, depending on the nutritional state: after injection into fed animals, heart LPL activity increased up to 477.2 mIU/g (P < 0.01) with a concomitant increase in the LPL synthesis rate. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
8 Hence, although insensitive to nutritional modulations, heart LPL responded differently to cyclophosphamide, depending on the nutritional state. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus
9 Hence, a defect of heart and postheparin plasma LPL appears as a major determinant of hypertriglyceridemia in cyclophosphamide-treated fasted rabbits. Cyclophosphamide lipoprotein lipase Oryctolagus cuniculus