Title : 13-cis-retinoic acid affects oxidation and DNA damage in oxidative-positive SLE lymphocytes but may not be useful for therapy.

Pub. Date : 1993 Feb

PMID : 8439447






1 Functional Relationships(s)
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1 13-cis-Retinoic acid (13-CRA), a water-soluble vitamin A analog and 5"-lipoxygenase inhibitor, was tested in vitro for effects on excess oxidative metabolism and DNA damage in mitogen-stimulated lymphocytes from patients with systemic lupus erythematosus (SLE), because other 5"-lipoxygenase enzyme inhibitors were shown to lower the excess oxidative metabolism in SLE cells. Isotretinoin myotubularin related protein 11 Homo sapiens