Title : Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

Pub. Date : 1993 Feb 1

PMID : 8430068






1 Functional Relationships(s)
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1 Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P). pyrene tumor protein p53 Homo sapiens