Title : Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture.

Pub. Date : 1993 Feb

PMID : 8418992






1 Functional Relationships(s)
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1 Treatment of BASMCs with benzyloxycarbonyl-Leu-norleucinal (calpeptin) at 100 microM and acetyl-Leu-Leu-norleucinal (TPI-1) at 50 microM was shown to cause a block of platelet-derived growth factor-BB as well as serum-inducible cell cycle progression at a point before the G1-S boundary, reducing the percentage of bromodeoxyuridine-positive cells from 87% to 5% over a 24-hour labeling period. Bromodeoxyuridine triosephosphate isomerase 1 Bos taurus