Title : Histidyl-proline diketopiperazine. Novel formation that does not originate from thyrotropin-releasing hormone.

Pub. Date : 1993 Oct 5

PMID : 8407917






3 Functional Relationships(s)
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1 Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed. pyroglutamylhistidine thyrotropin releasing hormone Homo sapiens
2 Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed. pyroglutamylhistidine thyrotropin releasing hormone Homo sapiens
3 Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed. pyroglutamylhistidine thyrotropin releasing hormone Homo sapiens