Title : Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells.

Pub. Date : 1993 Aug

PMID : 8396340






1 Functional Relationships(s)
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1 Using primary cultures of mouse renal JG cells, we found that sodium nitroprusside (SNP) and 3-morpholino-sydnonimin-hydrochloride (SIN-1), two structurally different liberators of NO, led to a transient inhibition during the first hour followed by a marked dose-dependent stimulation of renin secretion lasting for an additional 20 h. This stimulatory effect was blunted by methylene blue (50 microM) and was reversible within minutes after removal of the NO liberators. Methylene Blue mitogen-activated protein kinase associated protein 1 Mus musculus