Title : Tumor necrosis factor produces homologous desensitization of lymphocyte beta 2-adrenergic responses.

Pub. Date : 1993 Apr

PMID : 8387402






2 Functional Relationships(s)
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1 Isoproterenol-mediated cyclic-3,5-adenosine monophosphate (cAMP) production by intact lymphocytes preincubated with isotonic buffer or TNF alpha was studied. Isoproterenol tumor necrosis factor Homo sapiens
2 TNF alpha at 1 ng/ml and 100 ng/ml reduced isoproterenol-stimulated cAMP generation by 15% and 27% over the respective basal values. Isoproterenol tumor necrosis factor Homo sapiens