Pub. Date : 1993 Sep 25
PMID : 8376408
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As shown previously, TNF (1 nM) induced a marked increase in nuclear NF-kappa B binding in human leukemia (HL-60) cells within 5 min, and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase, 0.1 units.ml-1, induced a 50% reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10(6) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10(6) cells-1. | Ceramides | tumor necrosis factor | Homo sapiens |
| 2 | A cell-permeable ceramide analog, C8-ceramide, which mimics biologic effects of TNF-alpha, also enhanced nuclear NF-kappa B activation within minutes. | Ceramides | tumor necrosis factor | Homo sapiens |
| 3 | Further, TNF-alpha induced elevation in ceramide content by 2 min to 185% of control but did not affect DG levels. | Ceramides | tumor necrosis factor | Homo sapiens |