Pub. Date : 1993 Jul-Aug
PMID : 8352528
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with 25-hydroxycholesterol, an inhibitor of HMG CoA reductase activity, efficiently blocked the proliferation of both human normal mammary epithelial cells (HMEC) and breast cancer cells (MDA231). | 25-hydroxycholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Following a 25-hydroxycholesterol treatment as short as 4 h, the onset of DNA synthesis was delayed, indicating that a certain level of HMG CoA reductase activity (= mevalonate synthesis) in the early and mid stage of the prereplicative phase is required for the transduction of the signal leading to initiation of DNA synthesis. | 25-hydroxycholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |