Title : The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.

Pub. Date : 1993 Jul 30

PMID : 8325502






1 Functional Relationships(s)
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1 The single immunoblot-positive allele was found to contain a mutation altering a specific residue (Tyr89) which is conserved among the known FKBPs, and which, based on the solution and x-ray structures of human FKBP12, has been proposed to be part of a hydrophobic drug-binding pocket for FK506 and Rm. Tacrolimus FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens