Pub. Date : 1993 Jul
PMID : 8321238
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The transcription factor ADR1 is required to fully activate expression when glucose becomes depleted. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 2 | Partial activation during growth on glucose occurred in cells carrying a constitutive allele of ADR1 in which the phosphorylatable serine of a cyclic AMP (cAMP)-dependent protein kinase phosphorylation site had been changed to alanine. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 3 | When glucose was removed from the growth medium, a substantial increase in the level of this constitutive expression was observed for both the ADH2 gene and a reporter construct containing the ADR1 binding site. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 4 | This suggests that glucose can block ADR1-mediated activation independently of cAMP-dependent phosphorylation at serine 230. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 5 | Yeast strains carrying a deletion of the REG1 gene, reg1-1966, showed a large increase in ADR1-dependent expression of ADH2 during growth on glucose. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 6 | Our results suggest that glucose repression in the presence of ADR1 constitutive alleles occurs primarily through a REG1-dependent pathway which appears to affect ADH2 transcription at multiple levels. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |