Title : Regulatory mechanism of human factor IX gene: protein binding at the Leyden-specific region.

Pub. Date : 1994 Feb 15

PMID : 8312279






1 Functional Relationships(s)
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1 These findings suggest that the amelioration of hemophilia B-Leyden with a mutation at nt -20 after puberty involves binding of a specific non-androgen receptor nuclear protein at FP-III" and it is able to substitute for the function of a protein bound at FP-III in the normal gene optimally through its elevated interaction with androgen receptor upon a surge of testosterone. Testosterone androgen receptor Homo sapiens