Pub. Date : 1994 Jan 7
PMID : 8276860
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies have provided evidence that oncogenic Dbl or an associated protein stimulates GDP dissociation from the human species (Hs) homolog of CDC42. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 2 | We show here that Dbl specifically complexes with the GDP-bound forms of CDC42Hs and RhoA, but not Rac1 or TC10, and that this specificity correlates with the ability of Dbl to act as a GDP-releasing factor. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 3 | We show here that Dbl specifically complexes with the GDP-bound forms of CDC42Hs and RhoA, but not Rac1 or TC10, and that this specificity correlates with the ability of Dbl to act as a GDP-releasing factor. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 4 | Small deletions throughout the Dbl domain, which inactivate transformation, eliminated the ability of Dbl to stimulate GDP dissociation, whereas deletions outside of this domain did not impair either function. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 5 | Small deletions throughout the Dbl domain, which inactivate transformation, eliminated the ability of Dbl to stimulate GDP dissociation, whereas deletions outside of this domain did not impair either function. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 6 | Finally, the Dbl domain itself, when expressed and purified as a recombinant protein, was shown to stimulate GDP dissociation from purified, recombinant CDC42Hs. | Guanosine Diphosphate | MCF.2 cell line derived transforming sequence | Homo sapiens |