Title : Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB.

Pub. Date : 1994 Jan

PMID : 8264601






3 Functional Relationships(s)
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1 We have analyzed the activities of the transcription factors TFIIIB and TFIIIC derived from extracts prepared from TPA-induced and noninduced cells. Tetradecanoylphorbol Acetate Brf RNA polymerase III subunit Drosophila melanogaster
2 However, the activity of TFIIIB derived from the TPA-induced cells is substantially increased compared with that derived from the noninduced cells. Tetradecanoylphorbol Acetate Brf RNA polymerase III subunit Drosophila melanogaster
3 Together, these results indicate that the TPA response in Drosophila cells stimulates specific transcription of RNA polymerase III genes by increasing the activity of the limiting transcription component, TFIIIB, and thereby increasing the number of functional transcription complexes. Tetradecanoylphorbol Acetate Brf RNA polymerase III subunit Drosophila melanogaster