Title : Platelet-activating-factor-induced augmentation of production of eosinophil-lineage cells in hematopoietic precursor cells obtained from human umbilical cord blood.

Pub. Date : 1993

PMID : 8241800






3 Functional Relationships(s)
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1 IL-1 beta, IL-3 or IL-5 gene expression was detected in cellular RNA isolated from both medium- and PAF-stimulated CBMCs using the reverse transcription polymerase chain reaction (RT-PCR) method; however, no expression of GM-CSF was detected. cbmcs PCNA clamp associated factor Homo sapiens
2 Depletion of CD2+, CD16+ or CD19+ cells, but not CD14+ cells, from CBMCs resulted in a marked decrease in PAF-induced augmentation of eosinophil production. cbmcs PCNA clamp associated factor Homo sapiens
3 These results suggest that PAF induces the augmentation of IL-3 production in CBMCs which in turn enhances differentiation into eosinophil-lineage cells. cbmcs PCNA clamp associated factor Homo sapiens