Pub. Date : 1994 Jun 17
PMID : 8206972
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because lipoprotein lipase (LPL) increases the uptake of lipoproteins and lipid emulsion particles by many cell types including adipocytes, we investigated whether LPL also increases retinoid uptake by adipocytes from lipid-containing particles. | Retinoids | lipoprotein lipase | Oryctolagus cuniculus |
| 2 | Addition of LPL (10 micrograms/ml) to BFC-1 beta adipocytes produced a 2-fold increase in cellular uptake of [3H]retinoid from a lipid emulsion containing [3H]retinyl ester. | Retinoids | lipoprotein lipase | Oryctolagus cuniculus |
| 3 | Heparin, which displaces LPL from binding sites on cell surface proteoglycans, increased [3H]retinoid uptake by an additional 2-fold. | Retinoids | lipoprotein lipase | Oryctolagus cuniculus |
| 4 | Thus, LPL is able to catalyze the hydrolysis of retinyl esters and, through the process of hydrolysis, may facilitate uptake of retinoid by adipocytes. | Retinoids | lipoprotein lipase | Oryctolagus cuniculus |