Title : Enhanced production of nitric oxide by bone marrow cells and increased sensitivity to macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF after benzene treatment of mice.

Pub. Date : 1994 Jun 1

PMID : 8193360






2 Functional Relationships(s)
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1 Treatment of mice with the hematotoxicant benzene (800 mg/kg, intraperitoneally, two times per day, for 2 days) resulted in a significant increase in nitric oxide production by BM cells stimulated with lipopolysaccharide (LPS) and interferon gamma alone or in combination with M-CSF or GM-CSF. Benzene colony stimulating factor 1 (macrophage) Mus musculus
2 Cells from benzene-treated mice also displayed increased sensitivity to the growth-promoting effects of M-CSF and GM-CSF. Benzene colony stimulating factor 1 (macrophage) Mus musculus